Summary
It is safe to say that Isekai anime is a genre that most anime fans, if not all, are familiar with. This genre involves the reincarnation or transportation of the main character into an alternate universe or fantasy world. Most Isekai anime have male protagonists with female supporting characters, but one thing anime creators do is explore different storylines.
What a male character can do, a female character can also do, and vice versa. A genre can predominately be for female lead characters, like the magical girl genre, but best believe there issome magical boy anime out there. Isekai anime is not left behind, as some have female protagonists with males as the supporting characters.
Updated June 12, 2025, by Oluwatokiloba Folami:In the world of anime where anything is almost possible, there is agrowing list of isekai animethat places focus on strong female leads. This genre that typically focuses on male characters is centered on taking its characters away from their normal world to a fantastical and unfamiliar world where they have to live either permanently or temporarily.With the focus being placed on the female protagonist, a fresh perspective is added. These women or in the case of No Game, No Life, a girl, take charge and make things happen. These females also show that they have what it takes to be in the spotlight, either alone or alongside a male protagonist. They display great strength, and bravery and undergo significant personal/character development that might make fans adore them.
Mushoku Tensei Jobless Reincarnation
Mushoku Tensei: Jobless Reincarnationfollows the journey of aJapanese shut-inwho got hit by a truck and reincarnated in a world of magic as Rudeus Greayrat.As Rudeaus adapts to his new world, he makes friends and meets families. He meets Eris, his second cousin who is a force to be reckoned with. Eris is known for her short temper, but duringthe Teleport incident,fans got to know her more, and it is safe to assume that she has grown on fans.
Eris is one of the main protagonists of this animeand is particularly known for being violent, but she is also a determined young lady who spends her time obsessively trainingto become stronger.As the anime progresses, fans see her realize her dreams as she becomes strong and independent. To an extent, Eris can be considered proud, but she knows when to put her pride aside and accept help from someone she feels superior to, Rudeaus.
Kuma Kuma Kuma Beartells the story of Yuna and her adorable bear onesiethat turned out to be a powerhouse. Yuna finds herself stuck in a virtual reality game and has no choice but to explore when she realizes that there is no way out. Initially, she is embarrassed by the bear onesie she is wearing, but she accepts it once she realizes the important role it plays in making her powerful.
As Yuna journeys through the game world, she draws attention to herself not only because of her outfit but her incredible powers. She finds herself adjusting well to this new world and is not keen on returning to Earth. This 15-year-old takes her new world with bravery, helping people around her andliving a carefree life.
Shiro is part of the sibling duoSora and Shiro inNo Game, No Life. Shiro is achild protagonistin this anime, and although she is quite young, her impact cannot go unnoticed. Shiro is a shut-in who finds herself in the world of Disboard with her brotherafter defeating Tetin a game of chess.
Shiro is very calm and is the brains of the duo. She is brilliant and logical and analyzes situations to ensure a perfect outcome. Every move Sora and Shiro make as a team iscalculated by Shiro, and this is why they are notorious in the game world, and they never lose a game.
Hitomi is the main protagonist of this anime, and her life takes a drastic turn after she is transported from Earth to a mysterious world called Gaea. The average life of being a student she once lived is now a distant memory as she now has a bigger issue, which is to use her precognition powers to help Gaea in their ongoing war.
Hitomi embraces her powersand uses them the best way she can to favor Gaea in the war. Her growth and impact in this anime cannot go unnoticed as her 15-year-old self faces a lot of trials in this new world, taking her from a typical high school girl to a strong and independent woman in a short amount of time.
Spirited Away
Chihiro is a spoiled girl who gets whatever she wants whenever she wants it, but she is quick to grow up after a stop at an amusement park turns her parents into pigs, and sends her offto the spirit world. This isekai anime beautifully captures Chihiro’s growth as she strives to return to the human world and free her parents from captivity.
This protagonist is just ten years old, yet she possesses great bravery and courage as she navigates through a strange world, encountering magic as well as danger.
9So I’m A Spider, So What?
Kumoko
Before the protagonist of this anime became a spider, she was a high school student who died after an unexpected accident at her school, killing her and her classmates. Kumoko wakes up and discovers she has been reincarnated as a nameless spider. In addition to being the weakest and most fragile creature, she is also stuck in a basement and must escape in order not to die.
So I’m A Spider, So What?would not be the same without Kumoko’s fighting spirit. Even though she finds herself in an unfavorable position, she is still hopeful that her situation will get better and strives to make sure it is by fighting monsters and leveling up. She faces many obstacles that wear her down, but her willpower is admirable.
My Next Life as a Villainess: All Routes Lead to Doom!
Caterina reincarnates as the villain of her favorite otome game. As a villain, she is destined for doom. However, she does not quickly regain her memories from her previous life, and is oblivious to the true nature of her new life. This new Caterina is nice and full of love; she is always ready to help people whenever she can.
My Next Life As A Villainess: All Routes Lead to Doom!‘sleading lady is full of kindness, and it is this kindness that lets her dodge her fate. Once she regains her memories and is aware of her true nature and her destiny with doom, she sets out to avoid her fate by avoiding predestined troubles, befriending would-be rivals, and much more. This leading lady does not have or use swords or magic; rather, her weapon is kindness.
Didn’t I Say To Make My Abilities Average In The Next Life?!
Cast
Didn’t I Say to Make My Abilities Average in the Next Life?! is an anime series based on the light novel by FUNA. It follows the story of Kurihara Misato, who is reincarnated with extraordinary powers despite her wish to be average, leading her to navigate a new world filled with adventures and friendships.
Being special has its pros and cons, and Misato suffers the cons till she dies. Because she was special and could do more than what her peers could do, she had no friends and lived a very lonely life. After her death,she gets the golden chance to reincarnate into a fantasy world, and as someone who was beyond average in her previous life, Misato’s only wish in this new world is to be average and live a normal life.
This female protagonist receives the shock of her life as average turns out to be exceptional in this new world. Misato is now Adele, born with extraordinary magical abilities. Unlike her previous life, here she has two friends, and she tries to live an ordinary life regardless of her exceptional skills. Conclusively, her new life with her friends, who make a ridiculous combination of personalities while still trying to stay true to the idea of an isekai helps in selling the series.
I’ve Been Killing Slimes For 300 Years And Maxed Out My Level
Work-life balance is crucial, and one should endeavor to set aside time to rest and recuperate from daily stress and exhaustion. However, the main character of this isekai anime, Azusa, does not understand the importance of rest, and she dies from overworking and lack of rest.
After her death, she reincarnates asan immortal witch. This time around, she decides to live a stress-free and relaxing life. She spends most of her years killing slimes until she realizes she wants more than the peaceful and isolated life she has been living. Irrespective of its generic use of isekai themes, the pacing and non-seriousness of the series serve as one of its strongest points.
Studio 4°c
Number of Episodes
40
The female main character in this anime, Arusu, is a lover of magic. Arusu believes that magic should be used for fun and happiness, as this is what her father, Jidan, makes her believe. One fateful day, Arusu finds herself in a strange world, the Magical Realm. In this realm, she realizes that witches are the rulers of the land, which excites her so much because she loves witches.
Her love shatters the moment she realizes that they use their magic for evil rather than good. As a human, Arusu has quite a solid understanding of magic and can perform more than some of the witches in the Magical Realm. They see her as a threat, but that does not faze Arusu, as she is hell-bent on positively changing things in this realm. Conversely, while showcasing an individual’s love for magic, the accurate communication of how magic is actually a tool for wars and oppression sends a deeper message to viewers.
